Drug interactions
Naldemedine + Voriconazole
Severity: Moderate
Naldemedine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase naldemedine exposure. This could increase gastrointestinal adverse effects such as abdominal pain and diarrhea, and opioid withdrawal symptoms.
What this interaction means in plain words
Naldemedine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naldemedine belongs to Gastrointestinal Tract; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, the main metabolic pathway of naldemedine.
What to do
Monitor for abdominal pain, diarrhea and opioid withdrawal symptoms. Reduce or stop naldemedine if these are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Voriconazole?
MediHelp rates the interaction as moderate. Naldemedine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may increase naldemedine exposure. This could increase gastrointestinal adverse effects such as abdominal pain and diarrhea, and opioid withdrawal symptoms.
How serious is the interaction between Naldemedine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal pain, diarrhea and opioid withdrawal symptoms. Reduce or stop naldemedine if these are troublesome.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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