Drug interactions
Naproxen + Nitazoxanide
Severity: Minor
Naproxen and Nitazoxanide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of nitazoxanide is highly protein bound, and naproxen is also highly bound, so displacement is theoretically possible. No clinically important effect has been demonstrated.
What this interaction means in plain words
Naproxen and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naproxen belongs to Musculoskeletal; Nitazoxanide belongs to Anti Bacterial.
Why it happens
Theoretical competition for plasma protein binding sites.
What to do
No specific action is needed. Monitor for NSAID adverse effects if used together with other highly protein-bound drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Naproxen with Nitazoxanide?
MediHelp rates the interaction as minor. Naproxen and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The active metabolite of nitazoxanide is highly protein bound, and naproxen is also highly bound, so displacement is theoretically possible. No clinically important effect has been demonstrated.
How serious is the interaction between Naproxen and Nitazoxanide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Monitor for NSAID adverse effects if used together with other highly protein-bound drugs.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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