Drug interactions
Naproxen + Paromomycin
Severity: Minor
Naproxen and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, so systemic aminoglycoside exposure is negligible in most patients. The reduced clearance seen with NSAIDs and systemic aminoglycosides, mainly in preterm infants, is therefore of little relevance here.
What this interaction means in plain words
Naproxen and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naproxen belongs to Musculoskeletal; Paromomycin belongs to Anti Bacterial.
Why it happens
NSAID-related reduction in glomerular filtration could theoretically slow elimination of the small absorbed fraction of paromomycin.
What to do
No specific action is needed in patients with normal renal function. Monitor renal function if there is severe renal impairment or extensive gut ulceration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Naproxen with Paromomycin?
MediHelp rates the interaction as minor. Naproxen and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin is minimally absorbed, so systemic aminoglycoside exposure is negligible in most patients. The reduced clearance seen with NSAIDs and systemic aminoglycosides, mainly in preterm infants, is therefore of little relevance here.
How serious is the interaction between Naproxen and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed in patients with normal renal function. Monitor renal function if there is severe renal impairment or extensive gut ulceration.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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