Drug interactions
Naproxen + Sotalol
Severity: Moderate
Naproxen and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use can blunt the effect of beta-blockers by causing sodium and fluid retention and reducing vasodilatory prostaglandins. Blood pressure control may be reduced when naproxen is used with sotalol.
What this interaction means in plain words
Naproxen and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Sotalol belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal and vascular prostaglandin synthesis antagonizes the antihypertensive effect of the beta-blocker.
What to do
Monitor blood pressure and heart rate when naproxen is used regularly, and adjust the antihypertensive regimen if needed. Also check renal function and electrolytes because sotalol is renally cleared.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Naproxen and Sotalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Naproxen with Sotalol?
MediHelp rates the interaction as moderate. Naproxen and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged NSAID use can blunt the effect of beta-blockers by causing sodium and fluid retention and reducing vasodilatory prostaglandins. Blood pressure control may be reduced when naproxen is used with sotalol.
How serious is the interaction between Naproxen and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when naproxen is used regularly, and adjust the antihypertensive regimen if needed. Also check renal function and electrolytes because sotalol is renally cleared.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
