Drug interactions
Naproxen + Trazodone
Severity: Moderate
Naproxen and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has serotonergic activity that may impair platelet function, and combined with an NSAID this may raise the risk of gastrointestinal bleeding. The risk is lower than with potent SSRIs but is relevant in older or high-risk patients.
What this interaction means in plain words
Naproxen and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Serotonin reuptake inhibition reduces platelet serotonin and aggregation, adding to NSAID platelet inhibition and mucosal injury.
What to do
Monitor for signs of GI bleeding and consider gastroprotection in patients at high risk. Use the lowest effective naproxen dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Naproxen with Trazodone?
MediHelp rates the interaction as moderate. Naproxen and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has serotonergic activity that may impair platelet function, and combined with an NSAID this may raise the risk of gastrointestinal bleeding. The risk is lower than with potent SSRIs but is relevant in older or high-risk patients.
How serious is the interaction between Naproxen and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and consider gastroprotection in patients at high risk. Use the lowest effective naproxen dose.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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