Drug interactions
Naratriptan + Paliperidone
Severity: Moderate
Naratriptan and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans have been linked to serotonin syndrome, and antipsychotics with serotonin receptor activity may add to this risk in rare cases. Evidence for this combination is limited and the risk appears low.
What this interaction means in plain words
Naratriptan and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naratriptan belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; the mechanism is not firmly established.
What to do
Monitor for agitation, tremor, hyperthermia, clonus and autonomic instability after starting or changing doses. Stop the triptan if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Paliperidone?
MediHelp rates the interaction as moderate. Naratriptan and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans have been linked to serotonin syndrome, and antipsychotics with serotonin receptor activity may add to this risk in rare cases. Evidence for this combination is limited and the risk appears low.
How serious is the interaction between Naratriptan and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, clonus and autonomic instability after starting or changing doses. Stop the triptan if serotonin toxicity is suspected.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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