Drug interactions
Naratriptan + Pentazocine
Severity: Minor
Naratriptan and Pentazocine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A triptan with an opioid that has limited serotonergic activity could theoretically add to serotonin toxicity. The risk with pentazocine is thought to be low and is mostly extrapolated.
What this interaction means in plain words
Naratriptan and Pentazocine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naratriptan belongs to Central Nervous System; Pentazocine belongs to Musculoskeletal.
Why it happens
Possible additive serotonergic effects; not well established for pentazocine.
What to do
No routine change is needed. Advise patients to report agitation, tremor, sweating or fever and evaluate for serotonin syndrome if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Pentazocine?
MediHelp rates the interaction as minor. Naratriptan and Pentazocine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A triptan with an opioid that has limited serotonergic activity could theoretically add to serotonin toxicity. The risk with pentazocine is thought to be low and is mostly extrapolated.
How serious is the interaction between Naratriptan and Pentazocine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise patients to report agitation, tremor, sweating or fever and evaluate for serotonin syndrome if they occur.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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