Drug interactions
Natalizumab + Trastuzumab deruxtecan
Severity: Moderate
Natalizumab and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan frequently causes neutropenia and natalizumab reduces immune surveillance. Combination may increase the risk of serious infections.
What this interaction means in plain words
Natalizumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Natalizumab belongs to Gastrointestinal Tract; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression and immunosuppression.
What to do
Monitor complete blood counts and for signs of infection or neurological symptoms. Consider holding natalizumab during significant neutropenia or infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Natalizumab
- Natalizumab + Vedolizumab Contraindicated
- Axicabtagene ciloleucel + Natalizumab Major
- Baricitinib + Natalizumab Major
- Belatacept + Natalizumab Major
- Brexucabtagene autoleucel + Natalizumab Major
- Cabazitaxel + Natalizumab Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Natalizumab with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Natalizumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan frequently causes neutropenia and natalizumab reduces immune surveillance. Combination may increase the risk of serious infections.
How serious is the interaction between Natalizumab and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for signs of infection or neurological symptoms. Consider holding natalizumab during significant neutropenia or infection.
What other medicines interact with Natalizumab?
MediHelp also lists interactions of Natalizumab with, for example, Vedolizumab, Axicabtagene ciloleucel, Baricitinib. The full list is on the Natalizumab page.
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