Drug interactions
Nateglinide + Nevirapine
Severity: Minor
Nateglinide and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may modestly reduce nateglinide exposure because nateglinide is partly cleared by CYP3A4 and CYP2C9, both inducible by nevirapine. Glycemic control could worsen, though the effect is not well documented.
What this interaction means in plain words
Nateglinide and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nateglinide belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine enzyme induction may increase nateglinide metabolism; this is predicted rather than firmly established.
What to do
Monitor blood glucose after starting or stopping nevirapine and adjust nateglinide dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Nevirapine?
MediHelp rates the interaction as minor. Nateglinide and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine may modestly reduce nateglinide exposure because nateglinide is partly cleared by CYP3A4 and CYP2C9, both inducible by nevirapine. Glycemic control could worsen, though the effect is not well documented.
How serious is the interaction between Nateglinide and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping nevirapine and adjust nateglinide dose if control changes.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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