Drug interactions
Nateglinide + Pegvisomant
Severity: Moderate
Nateglinide and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone action and can improve insulin sensitivity, and hypoglycemia has been seen in diabetic patients on antidiabetic drugs. Nateglinide may therefore have a stronger effect.
What this interaction means in plain words
Nateglinide and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nateglinide belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism improves insulin sensitivity, adding to the insulin secretagogue effect of nateglinide.
What to do
Monitor blood glucose when pegvisomant is started or the dose changed. Reduce the nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Nateglinide with Pegvisomant?
MediHelp rates the interaction as moderate. Nateglinide and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant blocks growth hormone action and can improve insulin sensitivity, and hypoglycemia has been seen in diabetic patients on antidiabetic drugs. Nateglinide may therefore have a stronger effect.
How serious is the interaction between Nateglinide and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when pegvisomant is started or the dose changed. Reduce the nateglinide dose if hypoglycemia occurs.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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