Drug interactions
Nateglinide + Risperidone
Severity: Moderate
Nateglinide and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can raise blood glucose and reduce insulin sensitivity, which may reduce the effect of nateglinide. Glycemic control may worsen.
What this interaction means in plain words
Nateglinide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nateglinide belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: antipsychotic-induced insulin resistance opposes glucose lowering.
What to do
Monitor blood glucose and HbA1c, and adjust the nateglinide dose or add therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Risperidone?
MediHelp rates the interaction as moderate. Nateglinide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can raise blood glucose and reduce insulin sensitivity, which may reduce the effect of nateglinide. Glycemic control may worsen.
How serious is the interaction between Nateglinide and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c, and adjust the nateglinide dose or add therapy if control worsens.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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