Drug interactions
Nateglinide + Trazodone
Severity: Minor
Nateglinide and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants can alter glycemic control in diabetic patients, but the effect of trazodone with nateglinide is small and poorly characterized.
What this interaction means in plain words
Nateglinide and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nateglinide belongs to Endocrine; Trazodone belongs to Central Nervous System.
Why it happens
Possible additive pharmacodynamic effect on glucose homeostasis; the mechanism is not established.
What to do
No routine dose change is needed; check blood glucose after starting or stopping trazodone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Trazodone?
MediHelp rates the interaction as minor. Nateglinide and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antidepressants can alter glycemic control in diabetic patients, but the effect of trazodone with nateglinide is small and poorly characterized.
How serious is the interaction between Nateglinide and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; check blood glucose after starting or stopping trazodone.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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