Drug interactions
Nateglinide + Vadadustat
Severity: Minor
Nateglinide and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat is a substrate of renal organic anion transporters OAT1 and OAT3, and drugs that inhibit these transporters can raise vadadustat exposure. Higher exposure may cause an excessive or overly rapid rise in hemoglobin and more adverse effects. Nateglinide is listed as a possible inhibitor, but the clinical significance is uncertain.
What this interaction means in plain words
Nateglinide and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nateglinide belongs to Endocrine; Vadadustat belongs to Endocrine.
Why it happens
Possible inhibition of OAT1/OAT3-mediated renal transport of vadadustat, increasing its AUC; this is largely predicted rather than demonstrated.
What to do
Monitor hemoglobin regularly and adjust the vadadustat dose per labeling if the rise is too rapid. Watch for adverse effects such as hypertension and thrombotic events.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Nateglinide with Vadadustat?
MediHelp rates the interaction as minor. Nateglinide and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat is a substrate of renal organic anion transporters OAT1 and OAT3, and drugs that inhibit these transporters can raise vadadustat exposure. Higher exposure may cause an excessive or overly rapid rise in hemoglobin and more adverse effects. Nateglinide is listed as a possible inhibitor, but the clinical significance is uncertain.
How serious is the interaction between Nateglinide and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin regularly and adjust the vadadustat dose per labeling if the rise is too rapid. Watch for adverse effects such as hypertension and thrombotic events.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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