Drug interactions
Nebivolol + Nisoldipine
Severity: Moderate
Nebivolol and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so together they may cause excessive hypotension, dizziness or reflex-related effects. Beta-blockers can also worsen heart failure in patients with poor ventricular function when combined with a calcium channel blocker. Dihydropyridines like nisoldipine generally combine safely with beta-blockers.
What this interaction means in plain words
Nebivolol and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effect through vasodilation and beta-blockade.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug. Titrate doses gradually, especially in elderly patients or those with left ventricular dysfunction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nebivolol with Nisoldipine?
MediHelp rates the interaction as moderate. Nebivolol and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so together they may cause excessive hypotension, dizziness or reflex-related effects. Beta-blockers can also worsen heart failure in patients with poor ventricular function when combined with a calcium channel blocker. Dihydropyridines like nisoldipine generally combine safely with beta-blockers.
How serious is the interaction between Nebivolol and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug. Titrate doses gradually, especially in elderly patients or those with left ventricular dysfunction.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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