Drug interactions
Nebivolol + Perphenazine
Severity: Moderate
Nebivolol and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is a CYP2D6 substrate and inhibitor and may raise nebivolol concentrations. Additive hypotension may also occur, increasing the risk of bradycardia or dizziness.
What this interaction means in plain words
Nebivolol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Perphenazine inhibits CYP2D6 metabolism of nebivolol, with additive hypotensive effects.
What to do
Monitor heart rate and blood pressure when starting or adjusting perphenazine. Lower the nebivolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Nebivolol with Perphenazine?
MediHelp rates the interaction as moderate. Nebivolol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is a CYP2D6 substrate and inhibitor and may raise nebivolol concentrations. Additive hypotension may also occur, increasing the risk of bradycardia or dizziness.
How serious is the interaction between Nebivolol and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or adjusting perphenazine. Lower the nebivolol dose if bradycardia or hypotension develops.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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