Drug interactions
Nebivolol + Tipranavir
Severity: Moderate
Nebivolol and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is usually given with ritonavir, which inhibits CYP2D6 and may raise nebivolol exposure. This can produce bradycardia or hypotension. Tipranavir itself also has mixed inhibitory and inducing effects.
What this interaction means in plain words
Nebivolol and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Probable CYP2D6 inhibition by the ritonavir-boosted regimen increasing nebivolol levels.
What to do
Monitor heart rate and blood pressure when starting or stopping tipranavir. Lower nebivolol dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Nebivolol with Tipranavir?
MediHelp rates the interaction as moderate. Nebivolol and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir is usually given with ritonavir, which inhibits CYP2D6 and may raise nebivolol exposure. This can produce bradycardia or hypotension. Tipranavir itself also has mixed inhibitory and inducing effects.
How serious is the interaction between Nebivolol and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping tipranavir. Lower nebivolol dose if bradycardia or hypotension occurs.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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