Drug interactions
Nelfinavir + Trimipramine
Severity: Moderate
Nelfinavir and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and may raise trimipramine concentrations. Higher tricyclic levels increase the risk of sedation, anticholinergic effects, arrhythmias and QT prolongation.
What this interaction means in plain words
Nelfinavir and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nelfinavir belongs to Anti Virals; Trimipramine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of trimipramine by nelfinavir.
What to do
Start with a lower trimipramine dose and titrate by response and tolerability, monitoring ECG and trimipramine levels where available. Watch for signs of tricyclic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Trimipramine?
MediHelp rates the interaction as moderate. Nelfinavir and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and may raise trimipramine concentrations. Higher tricyclic levels increase the risk of sedation, anticholinergic effects, arrhythmias and QT prolongation.
How serious is the interaction between Nelfinavir and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower trimipramine dose and titrate by response and tolerability, monitoring ECG and trimipramine levels where available. Watch for signs of tricyclic toxicity.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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