Drug interactions
Nelfinavir + Zileuton
Severity: Moderate
Nelfinavir and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir is a CYP3A4 inhibitor and may increase zileuton exposure. This could heighten dose-related adverse effects including liver injury.
What this interaction means in plain words
Nelfinavir and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nelfinavir belongs to Anti Virals; Zileuton belongs to Respiratory.
Why it happens
Nelfinavir inhibits CYP3A4-mediated metabolism of zileuton.
What to do
Monitor ALT periodically and clinically for hepatotoxicity; lower or discontinue zileuton if abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Zileuton?
MediHelp rates the interaction as moderate. Nelfinavir and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir is a CYP3A4 inhibitor and may increase zileuton exposure. This could heighten dose-related adverse effects including liver injury.
How serious is the interaction between Nelfinavir and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT periodically and clinically for hepatotoxicity; lower or discontinue zileuton if abnormalities develop.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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