Drug interactions
Neomycin + Oxaliplatin
Severity: Minor
Neomycin and Oxaliplatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin causes neurotoxicity and, less often, kidney injury, and its nephrotoxicity and ototoxicity are far weaker than those of cisplatin. Oral neomycin is poorly absorbed, so additive kidney or ear injury is unlikely unless absorption rises through mucositis or renal impairment.
What this interaction means in plain words
Neomycin and Oxaliplatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Neomycin belongs to Anti Bacterial; Oxaliplatin belongs to Oncology.
Why it happens
Theoretical additive nephrotoxicity and ototoxicity that requires systemic aminoglycoside absorption.
What to do
No routine action is needed. Monitor serum creatinine if the patient has renal impairment, mucositis or prolonged neomycin use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Neomycin with Oxaliplatin?
MediHelp rates the interaction as minor. Neomycin and Oxaliplatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxaliplatin causes neurotoxicity and, less often, kidney injury, and its nephrotoxicity and ototoxicity are far weaker than those of cisplatin. Oral neomycin is poorly absorbed, so additive kidney or ear injury is unlikely unless absorption rises through mucositis or renal impairment.
How serious is the interaction between Neomycin and Oxaliplatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor serum creatinine if the patient has renal impairment, mucositis or prolonged neomycin use.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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