Drug interactions
Neomycin + Succinylcholine
Severity: Moderate
Neomycin and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides may prolong the effect of succinylcholine, with delayed recovery of breathing. Oral neomycin matters mainly when it is absorbed systemically.
What this interaction means in plain words
Neomycin and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Neomycin belongs to Anti Bacterial; Succinylcholine belongs to Musculoskeletal.
Why it happens
Aminoglycoside impairment of neuromuscular transmission adds to depolarizing blockade.
What to do
Monitor neuromuscular recovery and have ventilatory support available. Use the lowest effective succinylcholine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Neomycin with Succinylcholine?
MediHelp rates the interaction as moderate. Neomycin and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides may prolong the effect of succinylcholine, with delayed recovery of breathing. Oral neomycin matters mainly when it is absorbed systemically.
How serious is the interaction between Neomycin and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular recovery and have ventilatory support available. Use the lowest effective succinylcholine dose.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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