Drug interactions
Neostigmine + Trazodone
Severity: Minor
Neostigmine and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neostigmine enhances cholinergic transmission, while trazodone has only weak anticholinergic activity, so meaningful opposition is unlikely. Clinical consequences are not well documented.
What this interaction means in plain words
Neostigmine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Neostigmine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Theoretical pharmacodynamic opposition between cholinesterase inhibition and weak anticholinergic effects of trazodone.
What to do
No routine change is needed; monitor response to neostigmine if the indication is myasthenia gravis and trazodone is added.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Neostigmine and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Neostigmine
Frequently asked questions
Can I take Neostigmine with Trazodone?
MediHelp rates the interaction as minor. Neostigmine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Neostigmine enhances cholinergic transmission, while trazodone has only weak anticholinergic activity, so meaningful opposition is unlikely. Clinical consequences are not well documented.
How serious is the interaction between Neostigmine and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor response to neostigmine if the indication is myasthenia gravis and trazodone is added.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
