Drug interactions
Netupitant / palonosetron + Posaconazole
Severity: Moderate
Netupitant / palonosetron and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can raise netupitant exposure because netupitant is cleared mainly by CYP3A4. The increase is usually tolerated, but adverse effects such as headache, constipation and fatigue may be more frequent.
What this interaction means in plain words
Netupitant / palonosetron and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole inhibits CYP3A4, decreasing netupitant metabolism.
What to do
No dose adjustment is generally required; monitor for increased adverse effects of the antiemetic combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Netupitant / palonosetron with Posaconazole?
MediHelp rates the interaction as moderate. Netupitant / palonosetron and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can raise netupitant exposure because netupitant is cleared mainly by CYP3A4. The increase is usually tolerated, but adverse effects such as headache, constipation and fatigue may be more frequent.
How serious is the interaction between Netupitant / palonosetron and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor for increased adverse effects of the antiemetic combination.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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