Drug interactions
Nevirapine + Nifedipine
Severity: Moderate
Nevirapine and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower nifedipine concentrations, leading to reduced blood pressure or anti-anginal control. The effect is expected from enzyme induction, and some reports show a significant reduction with similar inducers.
What this interaction means in plain words
Nevirapine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Nifedipine belongs to Cardiovascular.
Why it happens
Nevirapine induces CYP3A4, increasing first-pass and systemic metabolism of nifedipine.
What to do
Monitor blood pressure and angina symptoms and titrate nifedipine upward as needed. Reduce the dose if nevirapine is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nevirapine and Nifedipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Nevirapine with Nifedipine?
MediHelp rates the interaction as moderate. Nevirapine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower nifedipine concentrations, leading to reduced blood pressure or anti-anginal control. The effect is expected from enzyme induction, and some reports show a significant reduction with similar inducers.
How serious is the interaction between Nevirapine and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and angina symptoms and titrate nifedipine upward as needed. Reduce the dose if nevirapine is discontinued.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
