Drug interactions
Nevirapine + Nilotinib
Severity: Major
Nevirapine and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine, a CYP3A4 inducer, is expected to lower nilotinib exposure and could compromise antileukemic efficacy. Nilotinib has a narrow therapeutic margin, so changes in exposure matter.
What this interaction means in plain words
Nevirapine and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nevirapine belongs to Anti Virals; Nilotinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by nevirapine increases nilotinib clearance.
What to do
Avoid the combination where possible and choose an alternative antiretroviral; if unavoidable, monitor response and consider nilotinib levels or dose adjustment with specialist input.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nevirapine with Nilotinib?
MediHelp rates the interaction as major. Nevirapine and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine, a CYP3A4 inducer, is expected to lower nilotinib exposure and could compromise antileukemic efficacy. Nilotinib has a narrow therapeutic margin, so changes in exposure matter.
How serious is the interaction between Nevirapine and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative antiretroviral; if unavoidable, monitor response and consider nilotinib levels or dose adjustment with specialist input.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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