Drug interactions
Nevirapine + Orlistat
Severity: Moderate
Nevirapine and Orlistat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loss of virological control has been reported in HIV patients taking orlistat with antiretrovirals, possibly from reduced absorption. This could lead to treatment failure and resistance.
What this interaction means in plain words
Nevirapine and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Orlistat belongs to Miscellaneous.
Why it happens
Orlistat may reduce gastrointestinal absorption of antiretrovirals, though the exact mechanism is not established.
What to do
Avoid orlistat in patients on nevirapine if possible; if used, monitor HIV viral load frequently and stop orlistat if viremia rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Frequently asked questions
Can I take Nevirapine with Orlistat?
MediHelp rates the interaction as moderate. Nevirapine and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loss of virological control has been reported in HIV patients taking orlistat with antiretrovirals, possibly from reduced absorption. This could lead to treatment failure and resistance.
How serious is the interaction between Nevirapine and Orlistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid orlistat in patients on nevirapine if possible; if used, monitor HIV viral load frequently and stop orlistat if viremia rises.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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