Drug interactions
Nevirapine + Pimavanserin
Severity: Moderate
Nevirapine and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inducers lower pimavanserin exposure and may reduce its antipsychotic efficacy. Nevirapine is a moderate inducer, so a clinically relevant reduction is plausible.
What this interaction means in plain words
Nevirapine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Pimavanserin belongs to Central Nervous System.
Why it happens
Nevirapine induces CYP3A4, the main pathway of pimavanserin clearance.
What to do
Monitor for loss of psychotic symptom control and increase the pimavanserin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Nevirapine with Pimavanserin?
MediHelp rates the interaction as moderate. Nevirapine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inducers lower pimavanserin exposure and may reduce its antipsychotic efficacy. Nevirapine is a moderate inducer, so a clinically relevant reduction is plausible.
How serious is the interaction between Nevirapine and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychotic symptom control and increase the pimavanserin dose if needed.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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