Drug interactions
Nevirapine + Pioglitazone
Severity: Minor
Nevirapine and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may modestly reduce pioglitazone exposure because CYP3A4 contributes to its metabolism, though CYP2C8 is the principal pathway. Glycemic control could be slightly affected.
What this interaction means in plain words
Nevirapine and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nevirapine belongs to Anti Virals; Pioglitazone belongs to Endocrine.
Why it happens
Nevirapine induction of CYP3A4 may increase pioglitazone metabolism.
What to do
Monitor blood glucose and HbA1c after starting or stopping nevirapine and adjust pioglitazone if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Pioglitazone
Frequently asked questions
Can I take Nevirapine with Pioglitazone?
MediHelp rates the interaction as minor. Nevirapine and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine may modestly reduce pioglitazone exposure because CYP3A4 contributes to its metabolism, though CYP2C8 is the principal pathway. Glycemic control could be slightly affected.
How serious is the interaction between Nevirapine and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping nevirapine and adjust pioglitazone if needed.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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