Drug interactions
Nevirapine + Quinine
Severity: Moderate
Nevirapine and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine is cleared mainly by CYP3A4, so nevirapine may reduce quinine levels and risk antimalarial treatment failure. Clinical data are limited.
What this interaction means in plain words
Nevirapine and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Quinine belongs to Anti Parasitic.
Why it happens
Nevirapine induces CYP3A4, increasing quinine metabolism.
What to do
Monitor for malaria treatment response and consider alternative or additional antimalarial therapy if response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Nevirapine with Quinine?
MediHelp rates the interaction as moderate. Nevirapine and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine is cleared mainly by CYP3A4, so nevirapine may reduce quinine levels and risk antimalarial treatment failure. Clinical data are limited.
How serious is the interaction between Nevirapine and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for malaria treatment response and consider alternative or additional antimalarial therapy if response is poor.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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