Drug interactions
Nevirapine + Rifabutin
Severity: Moderate
Nevirapine and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may reduce nevirapine levels modestly, while nevirapine may slightly raise rifabutin exposure. The combination is used in practice in tuberculosis and HIV coinfection.
What this interaction means in plain words
Nevirapine and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces CYP3A4 and CYP2B6, increasing nevirapine clearance.
What to do
If combined, use standard doses and monitor HIV viral load and nevirapine tolerability; watch for rifabutin toxicity such as uveitis and neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Nevirapine with Rifabutin?
MediHelp rates the interaction as moderate. Nevirapine and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and may reduce nevirapine levels modestly, while nevirapine may slightly raise rifabutin exposure. The combination is used in practice in tuberculosis and HIV coinfection.
How serious is the interaction between Nevirapine and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If combined, use standard doses and monitor HIV viral load and nevirapine tolerability; watch for rifabutin toxicity such as uveitis and neutropenia.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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