Drug interactions
Nevirapine + Selegiline
Severity: Minor
Nevirapine and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce selegiline exposure through enzyme induction, potentially weakening its effect. The interaction is predicted from mechanism with limited clinical data.
What this interaction means in plain words
Nevirapine and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nevirapine belongs to Anti Virals; Selegiline belongs to Central Nervous System.
Why it happens
Nevirapine induces CYP2B6 and CYP3A4, which contribute to selegiline metabolism.
What to do
Monitor motor symptom control and adjust selegiline dose if response declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Nevirapine with Selegiline?
MediHelp rates the interaction as minor. Nevirapine and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine may reduce selegiline exposure through enzyme induction, potentially weakening its effect. The interaction is predicted from mechanism with limited clinical data.
How serious is the interaction between Nevirapine and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptom control and adjust selegiline dose if response declines.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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