Drug interactions
Nevirapine + Sorafenib
Severity: Moderate
Nevirapine and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine is expected to reduce sorafenib exposure, which may reduce anticancer efficacy.
What this interaction means in plain words
Nevirapine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Sorafenib belongs to Oncology.
Why it happens
Nevirapine induces CYP3A4, a pathway for sorafenib oxidative metabolism.
What to do
Monitor tumor response and tolerability, and consider a non-inducing antiretroviral if efficacy is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Nevirapine with Sorafenib?
MediHelp rates the interaction as moderate. Nevirapine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine is expected to reduce sorafenib exposure, which may reduce anticancer efficacy.
How serious is the interaction between Nevirapine and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and tolerability, and consider a non-inducing antiretroviral if efficacy is a concern.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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