Drug interactions
Nevirapine + Tadalafil
Severity: Moderate
Nevirapine and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and can lower tadalafil concentrations. This may reduce tadalafil efficacy for erectile dysfunction or pulmonary arterial hypertension.
What this interaction means in plain words
Nevirapine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Tadalafil belongs to Genitourinary.
Why it happens
Induction of CYP3A4-mediated tadalafil metabolism by nevirapine.
What to do
Monitor clinical response to tadalafil and adjust the dose if efficacy is lost. In pulmonary hypertension, consider an alternative agent or monitor closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Tadalafil?
MediHelp rates the interaction as moderate. Nevirapine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and can lower tadalafil concentrations. This may reduce tadalafil efficacy for erectile dysfunction or pulmonary arterial hypertension.
How serious is the interaction between Nevirapine and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to tadalafil and adjust the dose if efficacy is lost. In pulmonary hypertension, consider an alternative agent or monitor closely.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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