Drug interactions
Nevirapine + Tolterodine
Severity: Minor
Nevirapine and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may reduce tolterodine concentrations. The effect is probably small in most patients, since CYP2D6 is the main clearance route, but may matter in poor CYP2D6 metabolisers.
What this interaction means in plain words
Nevirapine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nevirapine belongs to Anti Virals; Tolterodine belongs to Genitourinary.
Why it happens
Nevirapine induces CYP3A4, increasing tolterodine metabolism.
What to do
No empirical dose change is needed. Reassess symptom control and raise the tolterodine dose if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Tolterodine?
MediHelp rates the interaction as minor. Nevirapine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine induces CYP3A4 and may reduce tolterodine concentrations. The effect is probably small in most patients, since CYP2D6 is the main clearance route, but may matter in poor CYP2D6 metabolisers.
How serious is the interaction between Nevirapine and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Reassess symptom control and raise the tolterodine dose if efficacy is lost.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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