Drug interactions
Nevirapine + Tolvaptan
Severity: Moderate
Nevirapine and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce tolvaptan exposure and diminish its effect on serum sodium or renal outcomes. Labeling advises avoiding strong CYP3A inducers.
What this interaction means in plain words
Nevirapine and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Tolvaptan belongs to Endocrine.
Why it happens
Nevirapine induces CYP3A4, increasing tolvaptan metabolism.
What to do
Monitor serum sodium and clinical response, and increase the tolvaptan dose if needed. Consider alternatives if effect is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Nevirapine with Tolvaptan?
MediHelp rates the interaction as moderate. Nevirapine and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce tolvaptan exposure and diminish its effect on serum sodium or renal outcomes. Labeling advises avoiding strong CYP3A inducers.
How serious is the interaction between Nevirapine and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and clinical response, and increase the tolvaptan dose if needed. Consider alternatives if effect is lost.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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