Drug interactions
Nevirapine + Vinorelbine
Severity: Moderate
Nevirapine and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinorelbine is cleared by CYP3A4, and nevirapine may lower its concentrations, potentially reducing antitumor effect. Clinical data are limited.
What this interaction means in plain words
Nevirapine and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Vinorelbine belongs to Oncology.
Why it happens
Nevirapine induces CYP3A4, increasing vinorelbine metabolism.
What to do
Monitor tumor response and neutropenia, and consider an alternative non-inducing antiretroviral during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Vinorelbine
Frequently asked questions
Can I take Nevirapine with Vinorelbine?
MediHelp rates the interaction as moderate. Nevirapine and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vinorelbine is cleared by CYP3A4, and nevirapine may lower its concentrations, potentially reducing antitumor effect. Clinical data are limited.
How serious is the interaction between Nevirapine and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and neutropenia, and consider an alternative non-inducing antiretroviral during chemotherapy.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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