Drug interactions
Nicardipine + Nisoldipine
Severity: Moderate
Nicardipine and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dihydropyridine calcium channel blockers with the same pharmacology, so combining them gives no extra therapeutic benefit. It increases the risk of hypotension, edema, flushing, and reflex tachycardia.
What this interaction means in plain words
Nicardipine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Duplicate L-type calcium channel blockade causes additive vasodilation.
What to do
Avoid therapeutic duplication and use a single dihydropyridine. If a switch is being made, stop one agent before starting the other and monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nicardipine with Nisoldipine?
MediHelp rates the interaction as moderate. Nicardipine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dihydropyridine calcium channel blockers with the same pharmacology, so combining them gives no extra therapeutic benefit. It increases the risk of hypotension, edema, flushing, and reflex tachycardia.
How serious is the interaction between Nicardipine and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid therapeutic duplication and use a single dihydropyridine. If a switch is being made, stop one agent before starting the other and monitor blood pressure.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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