Drug interactions
Nicardipine + Osimertinib
Severity: Minor
Nicardipine and Osimertinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib is metabolized partly by CYP3A4, and a weak inhibitor like nicardipine is unlikely to change exposure meaningfully. Clinical impact is expected to be small.
What this interaction means in plain words
Nicardipine and Osimertinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Osimertinib belongs to Oncology.
Why it happens
Nicardipine weakly inhibits CYP3A4, which could slightly reduce osimertinib clearance.
What to do
No dose adjustment is needed; monitor for osimertinib adverse effects including QT prolongation if other risk factors exist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Osimertinib
Frequently asked questions
Can I take Nicardipine with Osimertinib?
MediHelp rates the interaction as minor. Nicardipine and Osimertinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Osimertinib is metabolized partly by CYP3A4, and a weak inhibitor like nicardipine is unlikely to change exposure meaningfully. Clinical impact is expected to be small.
How serious is the interaction between Nicardipine and Osimertinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for osimertinib adverse effects including QT prolongation if other risk factors exist.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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