Drug interactions
Nicardipine + Ospemifene
Severity: Minor
Nicardipine and Ospemifene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits CYP2C9 and CYP3A4 in vitro, and both enzymes participate in ospemifene metabolism. Ospemifene exposure could be raised, increasing estrogen-agonist or antagonist effects, but clinical data are limited.
What this interaction means in plain words
Nicardipine and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Ospemifene belongs to Endocrine.
Why it happens
Nicardipine may inhibit CYP2C9 and CYP3A4 metabolism of ospemifene, based mainly on in vitro and predicted effects.
What to do
No routine adjustment is needed. Monitor for ospemifene adverse effects such as hot flushes, headache, or vaginal discharge if the combination is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Nicardipine with Ospemifene?
MediHelp rates the interaction as minor. Nicardipine and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine inhibits CYP2C9 and CYP3A4 in vitro, and both enzymes participate in ospemifene metabolism. Ospemifene exposure could be raised, increasing estrogen-agonist or antagonist effects, but clinical data are limited.
How serious is the interaction between Nicardipine and Ospemifene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for ospemifene adverse effects such as hot flushes, headache, or vaginal discharge if the combination is used.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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