Drug interactions
Nicardipine + Paliperidone
Severity: Minor
Nicardipine and Paliperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly raise paliperidone exposure by inhibiting P-glycoprotein. Paliperidone is a P-gp substrate, so increased sedation, orthostasis or QT effects are theoretically possible.
What this interaction means in plain words
Nicardipine and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Paliperidone belongs to Central Nervous System.
Why it happens
Inhibition of intestinal and renal P-glycoprotein efflux of paliperidone by nicardipine.
What to do
No empirical dose change is needed. Monitor for sedation, orthostatic hypotension and extrapyramidal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Nicardipine with Paliperidone?
MediHelp rates the interaction as minor. Nicardipine and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may modestly raise paliperidone exposure by inhibiting P-glycoprotein. Paliperidone is a P-gp substrate, so increased sedation, orthostasis or QT effects are theoretically possible.
How serious is the interaction between Nicardipine and Paliperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for sedation, orthostatic hypotension and extrapyramidal symptoms.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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