Drug interactions
Nicardipine + Pomalidomide
Severity: Minor
Nicardipine and Pomalidomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is cleared partly by CYP3A4 and P-gp, and nicardipine inhibits both weakly. A clinically meaningful rise in pomalidomide exposure is unlikely, as only strong dual inhibitors produced significant changes.
What this interaction means in plain words
Nicardipine and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Pomalidomide belongs to Miscellaneous.
Why it happens
Nicardipine weakly inhibits CYP3A4 and P-glycoprotein, which could slightly reduce pomalidomide clearance.
What to do
No adjustment is generally needed; monitor blood counts as part of routine pomalidomide care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Nicardipine with Pomalidomide?
MediHelp rates the interaction as minor. Nicardipine and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pomalidomide is cleared partly by CYP3A4 and P-gp, and nicardipine inhibits both weakly. A clinically meaningful rise in pomalidomide exposure is unlikely, as only strong dual inhibitors produced significant changes.
How serious is the interaction between Nicardipine and Pomalidomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is generally needed; monitor blood counts as part of routine pomalidomide care.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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