Drug interactions
Nicardipine + Ribociclib
Severity: Moderate
Nicardipine and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may increase ribociclib levels through CYP3A4 inhibition. Ribociclib prolongs the QT interval and causes neutropenia, so higher exposure raises these risks.
What this interaction means in plain words
Nicardipine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 reduces ribociclib clearance.
What to do
Monitor ECG, electrolytes and blood counts according to ribociclib labeling. Reduce the dose if QT prolongation or severe neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Nicardipine with Ribociclib?
MediHelp rates the interaction as moderate. Nicardipine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may increase ribociclib levels through CYP3A4 inhibition. Ribociclib prolongs the QT interval and causes neutropenia, so higher exposure raises these risks.
How serious is the interaction between Nicardipine and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, electrolytes and blood counts according to ribociclib labeling. Reduce the dose if QT prolongation or severe neutropenia occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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