Drug interactions
Nicardipine + Rivaroxaban
Severity: Moderate
Nicardipine and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a moderate CYP3A4 inhibitor and P-gp inhibitor and may modestly increase rivaroxaban exposure. This could raise bleeding risk, mainly in patients with renal impairment.
What this interaction means in plain words
Nicardipine and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Rivaroxaban belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by nicardipine reduces rivaroxaban clearance.
What to do
No dose change is generally needed with normal renal function. Monitor for bleeding, and be more cautious in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Nicardipine with Rivaroxaban?
MediHelp rates the interaction as moderate. Nicardipine and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a moderate CYP3A4 inhibitor and P-gp inhibitor and may modestly increase rivaroxaban exposure. This could raise bleeding risk, mainly in patients with renal impairment.
How serious is the interaction between Nicardipine and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed with normal renal function. Monitor for bleeding, and be more cautious in patients with renal impairment.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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