Drug interactions
Nicardipine + Saxagliptin
Severity: Minor
Nicardipine and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak to moderate CYP3A4 inhibitor and may modestly raise saxagliptin and its active metabolite levels. The effect is small compared with strong inhibitors and is rarely clinically important.
What this interaction means in plain words
Nicardipine and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Saxagliptin belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4/5-mediated saxagliptin metabolism by nicardipine.
What to do
No dose change is normally needed; the 2.5 mg/day limit applies to strong CYP3A4 inhibitors. Monitor glycemic control and adverse effects if therapy is combined.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Nicardipine with Saxagliptin?
MediHelp rates the interaction as minor. Nicardipine and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a weak to moderate CYP3A4 inhibitor and may modestly raise saxagliptin and its active metabolite levels. The effect is small compared with strong inhibitors and is rarely clinically important.
How serious is the interaction between Nicardipine and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; the 2.5 mg/day limit applies to strong CYP3A4 inhibitors. Monitor glycemic control and adverse effects if therapy is combined.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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