Drug interactions
Nicardipine + Sirolimus
Severity: Moderate
Nicardipine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine can increase sirolimus concentrations, possibly raising risks of immunosuppressant toxicity such as hyperlipidemia, cytopenias and impaired wound healing.
What this interaction means in plain words
Nicardipine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Sirolimus belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by nicardipine reduces sirolimus clearance.
What to do
Monitor sirolimus trough concentrations when starting or stopping nicardipine. Adjust the sirolimus dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Nicardipine with Sirolimus?
MediHelp rates the interaction as moderate. Nicardipine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine can increase sirolimus concentrations, possibly raising risks of immunosuppressant toxicity such as hyperlipidemia, cytopenias and impaired wound healing.
How serious is the interaction between Nicardipine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations when starting or stopping nicardipine. Adjust the sirolimus dose as needed.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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