Drug interactions
Nicardipine + Sonidegib
Severity: Moderate
Nicardipine and Sonidegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sonidegib is metabolized by CYP3A4, and nicardipine may modestly increase its exposure. This could raise the risk of musculoskeletal toxicity such as myopathy and creatine kinase elevation.
What this interaction means in plain words
Nicardipine and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Sonidegib belongs to Oncology.
Why it happens
Nicardipine weakly inhibits CYP3A4, reducing sonidegib clearance.
What to do
Monitor for muscle pain, weakness and creatine kinase elevation. Consider a non-CYP3A4-inhibiting antihypertensive if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Nicardipine with Sonidegib?
MediHelp rates the interaction as moderate. Nicardipine and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sonidegib is metabolized by CYP3A4, and nicardipine may modestly increase its exposure. This could raise the risk of musculoskeletal toxicity such as myopathy and creatine kinase elevation.
How serious is the interaction between Nicardipine and Sonidegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and creatine kinase elevation. Consider a non-CYP3A4-inhibiting antihypertensive if symptoms arise.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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