Drug interactions
Nicardipine + Tazemetostat
Severity: Moderate
Nicardipine and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer, which may lower nicardipine levels. Nicardipine has some CYP3A4 inhibitory activity and could slightly raise tazemetostat exposure. Both effects are probably modest.
What this interaction means in plain words
Nicardipine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, and nicardipine may weakly inhibit CYP3A4 metabolism of tazemetostat.
What to do
Monitor blood pressure and adjust nicardipine as needed. Monitor for tazemetostat adverse effects such as cytopenias and fatigue.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Tazemetostat
Frequently asked questions
Can I take Nicardipine with Tazemetostat?
MediHelp rates the interaction as moderate. Nicardipine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A4 inducer, which may lower nicardipine levels. Nicardipine has some CYP3A4 inhibitory activity and could slightly raise tazemetostat exposure. Both effects are probably modest.
How serious is the interaction between Nicardipine and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust nicardipine as needed. Monitor for tazemetostat adverse effects such as cytopenias and fatigue.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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