Drug interactions
Nicardipine + Vemurafenib
Severity: Moderate
Nicardipine and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly inhibit CYP3A4, which contributes to vemurafenib metabolism. Vemurafenib exposure might rise, with a potential for QT prolongation, rash and photosensitivity. The effect is expected to be modest because nicardipine is not a strong inhibitor.
What this interaction means in plain words
Nicardipine and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Vemurafenib belongs to Oncology.
Why it happens
Nicardipine weakly to moderately inhibits CYP3A4, potentially decreasing vemurafenib clearance.
What to do
Monitor ECG and electrolytes and watch for vemurafenib toxicity; consider an alternative antihypertensive if QT concerns exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Vemurafenib
Frequently asked questions
Can I take Nicardipine with Vemurafenib?
MediHelp rates the interaction as moderate. Nicardipine and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may modestly inhibit CYP3A4, which contributes to vemurafenib metabolism. Vemurafenib exposure might rise, with a potential for QT prolongation, rash and photosensitivity. The effect is expected to be modest because nicardipine is not a strong inhibitor.
How serious is the interaction between Nicardipine and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and watch for vemurafenib toxicity; consider an alternative antihypertensive if QT concerns exist.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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