Drug interactions
Nicardipine + Voriconazole
Severity: Moderate
Nicardipine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4, which is a major route of nicardipine clearance, so nicardipine exposure may rise. This can cause excessive hypotension, flushing, headache, tachycardia and peripheral edema.
What this interaction means in plain words
Nicardipine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 (and CYP2C9) by voriconazole decreases nicardipine metabolism.
What to do
Monitor blood pressure and heart rate when starting or stopping voriconazole and reduce the nicardipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Voriconazole?
MediHelp rates the interaction as moderate. Nicardipine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4, which is a major route of nicardipine clearance, so nicardipine exposure may rise. This can cause excessive hypotension, flushing, headache, tachycardia and peripheral edema.
How serious is the interaction between Nicardipine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping voriconazole and reduce the nicardipine dose if hypotension or edema develops.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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