Drug interactions
Nifedipine + Ranolazine
Severity: Minor
Nifedipine and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine is a CYP3A4 substrate and is also a weak inhibitor of CYP3A4 and P-gp, while nifedipine is only a weak CYP3A4 inhibitor. Any increase in ranolazine exposure is expected to be small, but the combination adds antianginal effect and may increase dizziness or hypotension.
What this interaction means in plain words
Nifedipine and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Ranolazine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by nifedipine may slightly raise ranolazine levels, with additive hemodynamic effects.
What to do
No dose adjustment is usually needed. Monitor blood pressure and QT-related symptoms, and check for dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Nifedipine with Ranolazine?
MediHelp rates the interaction as minor. Nifedipine and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine is a CYP3A4 substrate and is also a weak inhibitor of CYP3A4 and P-gp, while nifedipine is only a weak CYP3A4 inhibitor. Any increase in ranolazine exposure is expected to be small, but the combination adds antianginal effect and may increase dizziness or hypotension.
How serious is the interaction between Nifedipine and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor blood pressure and QT-related symptoms, and check for dizziness.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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