Drug interactions
Nifedipine + Risperidone
Severity: Minor
Nifedipine and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine may weakly inhibit P-glycoprotein, which could slightly increase risperidone and 9-hydroxyrisperidone exposure. A clinically important effect is unlikely. Additive hypotension is a more practical concern.
What this interaction means in plain words
Nifedipine and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Risperidone belongs to Central Nervous System.
Why it happens
Possible weak P-glycoprotein inhibition by nifedipine; additive hypotensive effects.
What to do
No dose adjustment is routinely needed. Monitor for orthostatic hypotension and extrapyramidal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Nifedipine with Risperidone?
MediHelp rates the interaction as minor. Nifedipine and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine may weakly inhibit P-glycoprotein, which could slightly increase risperidone and 9-hydroxyrisperidone exposure. A clinically important effect is unlikely. Additive hypotension is a more practical concern.
How serious is the interaction between Nifedipine and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed. Monitor for orthostatic hypotension and extrapyramidal symptoms.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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